Zhou Lab Publications

Full list of publication in Google Scholar.

First Author (*) and Corresponding Author (#)

Lab members

2023

  1. Wang M, Lu YA, Zhou X, Lu R, Zhou Y. Abstract P1116: Histone Deacetylase Complexes Regulate Direct Cardiac Conversion From Human Fibroblasts. Circulation Research, 2023 Oct; 133.suppl_1:AP1116

  2. Lu YA, Sun J, Wang L, Wang M, Matthews R, Zhang J, Zhou Y. Abstract P1107: Elmsan1 Regulates Differentiation And Maturation Of Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells. Circulation Research, 2023 Oct; 133.suppl_1:AP1107

  3. Sun J, Wang L, Matthews RC, Walcott GP, Lu YA, Wei Y, Zhou Y, Zangi L, Zhang J. CCND2 Modified mRNA Activates Cell Cycle of Cardiomyocytes in Hearts With Myocardial Infarction in Mice and Pigs. Circulation Research.  2023 Aug 11;133:488-504

  4. Nguyen T, Wei Y, Nakada Y, Chen JY, Zhou Y, Walcott G, Zhang J. Analysis of cardiac single-cell RNA-sequencing data can be improved by the use of artificial-intelligence-based tools Scientific Reports 2023 13 (1), 6821

  5. Wang L, Nguyen T, Rosa-Garrido M, Zhou Y, Cleveland DC, Zhang J. Comparative analysis of the cardiomyocyte differentiation potential of induced pluripotent stem cells reprogrammed from human atrial or ventricular fibroblasts. Frontiers in Bioengineering and Biotechnology, 2023 Feb 10;11

2022

  1. Nakada Y, Zhou Y, Gong W, Zhang E, Skie E, Nguyen T, Wei Y, Zhao M, Chen W, Sun J, Chen J, Raza S, Walcott G, Garry DJ, Zhang J. Abstract 19014: Single Nucleus Transcriptomics Analysis of Extended the Myocardial Regenerative Window in Swine Hearts. Circulation Research. 2022 Dec; 131:e169–e190

  2. LU YA, Wang M, Sun J, Zhang J, Zhou Y. Abstract 19722: Stage-Specific Roles of ELMSAN1 in the Control of Cardiac Cell Fate Differentiation of Human-Induced Pluripotent Stem Cells. Circulation Research. 2022 Dec; 131:e169–e190

  3. Wang L, Sun J, Zhou Y, Wei Y, Zhang J. Abstract 10618: Modified Rna Ccnd2 Promotes Myocardial Remuscularization in Lv Infarct by Regulating Cardiomyocyte Cell Cycle. Circulation. 2022 Oct; 146 (Suppl_1): A10618

  4. Tang Y*, Sajesan A*, Geng X, Zhou X, Fast V, Zhang J, Lu R#, Zhou Y#. TBX20 Improves Contractility and Mitochondrial Function during Direct Human Cardiac Reprogramming. Circulation. 2022 Sep 14; 14:101161CIRCULATIONAHA122059713. Epub ahead of print.

  5. Lyra-Leite DM, Gutiérrez-Gutiérrez Ó, Wang M, Zhou Y, Cyganek L, Burridge PW. A Review of Protocols for Human iPSC Culture, Cardiac Differentiation, Subtype-Specification, Maturation, and Direct Reprogramming. Star Protocols. 2022 Sep 16;3(3):101560.

  6. Nguyen TM, Wei Y, Nakada Y, Zhou Y, Zhang J. Cardiomyocyte cell-cycle regulation in neonatal large mammals: Single Nucleus RNA-sequencing Data analysis via an Artificial-intelligence–based pipeline. Frontiers in Bioengineering and Biotechnology. 2022 Jul 4;10:914450.

  7. Nakada Y, Zhou Y, Gong W, Zhang ER, Skie E, Nguyen T, Wei T, Zhao M, Chen W, Sun J, Raza SN, Chen JY, Walcott GP, Garry DJ, Zhang J. Single Nucleus Transcriptomics: Apical Resection in Newborn Pigs Extends the Time Window of Cardiomyocyte Proliferation and Myocardial Regeneration. Circulation. 2022;145:1744–1747

  8. Zhou Y#, Zhang J. Remuscularization of Ventricular Infarcts Using the Existing Cardiac Cells. Advanced Technologies in Cardiovascular Bioengineering, Springer. 2022: 51-78

2021

  1. Chen W, Pretorius D, Zhou Y, Nakada Y, Yang J, and Zhang J. TT-10–loaded nanoparticles promote cardiomyocyte proliferation and cardiac repair in a mouse model of myocardial infarction. JCI Insight. 2021;6(20):e151987

  2. Zhou Y, Tang Y, Lu R, Zhang J. Abstract 12780: TBX20 Improves Contractility and Mitochondrial Function During Direct Cardiac Reprogramming From Human Fibroblasts. Circulation. 2021 Nov;144 (Suppl_1), A12780-A12780

  3. Tang Y, Zhou X, Zhang J, Lu R, Zhou Y. Abstract 11230: Coordinate Cistrome Regulation by Reprogramming Factors During Direct Human Cardiac Reprogramming. Circulation. 2021 Nov;144 (Suppl_1), A11230-A11230

  4. Nakada Y, Zhou Y, Gong W, Skie E, Zhang EY, Nguyen T, Wei Y, Zhao M, Chen W, Sun J, Chen JY, Walcott GP, Garry DJ, Zhang J. Abstract 9528: Apical Resection in Newborn Pig Hearts Extends the Regenerative Window of Cardiomyocyte. Circulation. 2021 Nov 16;144(Suppl_1):A9528-A9528.

  5. Chen W, Pretorius D, Zhou Y, Zhang J.  Abstract 9369: Nanoparticle-mediated Delivery of TT-10 Promotes Cardiomyocyte Proliferation and Myocardial Repair. Circulation. 2021 Nov 16;144(Suppl_1): A9369-A9369

  6. Zhao L, Zhang P, Galbo Jr PM, Zhou X, Aryal S, Qiu S, Zhang H, Zhou Y, Li C, Zheng D, Bhatia R, Lu R. Transcription Factor MEF2D is Required for the Maintenance of MLL-rearranged Acute Myeloid Leukemia. Blood Advances. 2021;2021004469.

  7. Chen W, Pretorius D, Zhou Y, Zhang J. Abstract P335: Nanoparticle-mediated Delivery Of TT-10 Promotes Myocardial Repair. Circulation Research. 2021 Sep 3;129(Suppl_1):AP335-AP335.

  8. Bian W, Chen W, Zhou Y, Zhang J. miR-199a Overexpression Enhances the Potency of Human Induced-pluripotent Stem-cell-derived Cardiomyocytes for Myocardial Repair. Frontiers in Pharmacology. 2021;12:1359.

  9. Zhao M, Nakada Y, Wei Y, Bian W, Chu Y, Borovjagin A, Xie M, Zhu W, Nguyen T, Zhou Y, Serpooshan V, Walcott G, and Zhang J. Cyclin D2 Overexpression Enhances the Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial Repair in a Swine Model of Myocardial Infarction. Circulation. 2021 May 6

  10. Tang Y, Zhao L, Yu X, Zhang J, Qian L, Jin J, Lu R, Zhou Y. Inhibition of EZH2 primes the cardiac gene activation via removal of epigenetic repression during human direct cardiac reprogramming. Stem Cell Research. 27 April 2021 102365

    Highlight Editor's Choice: 2021 Highlights

  11. Chen W, Bian W, Zhou Y, Zhang J. Cardiac Fibroblasts and Myocardial Regeneration. Front. Bioeng. Biotechnol., 25 March 2021

  12. Bishop SP, Zhou Y, Nakada Y, and Zhang J. Changes in Cardiomyocyte Cell Cycle and Hypertrophic Growth during Fetal to Adult in Mammals. Journal of the American Heart Association. 2021 Jan 5l; 10, e017839

2020

  1. Wang L, Ma H, Huang P, Xie Y, Near D, Wang H, Xu J, Yang Y, Xu Y, Garbutt T, Zhou Y, Liu Z, Yin C, Bressan M, Taylor JM, Liu J and Qian L. Downregulation of Beclin1 promotes direct cardiac reprogramming. Sci Transl Med. 2020 Oct 21;12(566)

  2. Zhang, H*, Zhang, Y*, Zhou, X*, Wright, S, Hyle, J, Zhao, L, An, J, Zhao, X, Shao, Y, Xu, B, Lee, H.M, Chen T, Zhou, Y, Chen, X, Lu, R and Li C. FFunctional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen. eLife 2020. 9, p.e57858.

  3. Zhao M*, Zhang E*, Wei Y, Zhou Y, Walcott G, Zhang J. Apical Resection Prolongs the Cell Cycle Activity and Promotes Myocardial Regeneration after LV Injury in Neonatal Pig. Circulation 2020 142:913–916

  4. Zhou Y, Tang Y, Zhao L, Lu R, Zhang J. Abstract 442: Epigenetic Regulation of Ezh2 in Direct Human Cardiac Reprogramming. Circulation Research. 2020 Jul 31;127 (Suupl_1): A442-A442 (Abstract)

  5. Zhou Y, Tang Y, Fast VG, Zhao L, Lu R, Zhang J. Abstract 103: TBX20 Activates Cardiac Maturation Gene Programs Promoting Direct Human Cardiac Reprogramming. Circulation Research. 2020 Jul 31;127 (Suupl_1): A103-A103.

  6. Garbutt, T*, Zhou Y*#, Keepers B, Liu J, Qian L#. An Optimized Protocol for Human Direct Cardiac Reprogramming. STAR Protocols. 2020 Jun 3:100010. (*Co-first authors, #Co-corresponding authors)

  7. Zhou Y, Zhang J#. Single-cell Transcriptomics: New Insights in Heart Research. Circulation. 2020 May 26; 141 (21), 1720-1723. 

  8. Zhang H*, Zhang Y*, Wright S, Hyle J, Zhao L, An J, Zhou X, Zhao X, Shao Y, Lee H, Chen T, Zhou Y, Lu R, Li C. Functional Interrogation of HOXA9 Regulome in MLLr Leukemia via Reporter-based CRISPR/Cas9 screen. bioRxiv. 2020 Jan 1.

2019

  1. Fang Z*, Liu X*, Wen J, Tang F, Zhou Y, Jing N, Jin Y. SOX21 Ensures Rostral Forebrain Identity by Suppression of WNT8B during Neural Regionalization of Human Embryonic Stem Cells. Stem cell reports 2019,13 (6), 1038-1052.

  2. Zhao M*, Tang Y*, Zhou Y, Zhang J. Deciphering Role of Wnt Signalling in Cardiac Mesoderm and Cardiomyocyte Differentiation from Human iPSCs: Four-dimensional control of Wnt pathway for hiPSC-CMs differentiation. Scientific Reports. 2019  9 (1), 1-15.

  3. Zhou Y*, Liu Z*, Welch JD, Gao X, Wang L, Ma H, Garbutt T, Huang PS, Vaseghi HR, Yin C, Prins JF, Shen W, Liu J, Qian L. Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming. Cell Stem Cell. 2019 Jul 3;25(1):149-64

  4. Zhou Y, Liu J, Qian L. Epigenomic reprogramming in cardiovascular disease. Computational epigenetics and diseases, Elsevier. 2019:149-163.

2014-2018

  1. Zhou Y, Alimohamadi S, Wang L, Liu Z, Wall JB, Yin C, Liu J, Qian L. A loss of function screen of epigenetic modifiers and splicing factors during early stage of cardiac reprogramming. Stem cells international. 2018 Mar 18;2018.

  2. Liu Z, Wang L, Welch JD, Ma H, Zhou Y, Vaseghi HR, Yu S, Wall JB, Alimohamadi S, Zheng M, Yin C, Shen W, Prins JF, Liu J, Qian L. Single-cell transcriptomics reconstructs fate conversion from fibroblast to cardiomyocyte. Nature. 2017 Nov 2;551(7678):100-104.

  3. Zhou Y, Wang L, Liu Z, Alimohamadi S, Liu J, Qian L. Comparative gene expression analyses reveal distinct molecular signature between differentially reprogrammed cardiomyocytes. Cell Reports. 2017 Sep 26;20(13):3014-3024.

  4. Liu Z, Chen O, Wall JB, Zheng M, Zhou Y, Wang L, Vaseghi H, Qian L, Liu J. Systematic comparison of 2A peptides for cloning multi-genes in a polycistronic vector. Scientific Reports. 2017 May 19;7(1):2193.

  5. Zhou Y, Qian L. Advanced technologies lead iNto new reprogramming routes. Cell Stem Cell. 2016 Sep 1;19(3):286-8.

  6. Ju XC, Hou QQ, Sheng ALS, Wu KY, Zhou Y, Jin Y, Wen T, Yang Z, Wang X, Luo ZG. The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice. Elife. 2016 Aug 9;5. 

  7. Vaseghi HR, Yin C, Zhou Y, Wang L, Liu J, Qian L. Generation of an inducible fibroblast cell line for studying direct cardiac reprogramming. Genesis. 2016 Jul;54(7):398-406.

  8. Lu R, Wang P, Parton T, Zhou Y, Chrysovergis K, Rockowitz S, Chen WY, Abdel-Wahab O, Wade PA, Zheng D, Wang GG. Epigenetic perturbations by Arg882-mutated DNMT3A potentiate aberrant stem cell gene-expression program and acute leukemia development. Cancer Cell. 2016 Jul 11; 30(1):92-107. 

  9. Zhou Y, Alimohamadi S, Liu J, Qian L. Abstract 35: Enhanced Reprogramming of Human Fibroblasts into Cardiomyocytes Using Minimal Transcription Factors. Circulation Research. 2016 Jul;119 (suppl_1), A35-A35

  10. Liu Z, Chen O, Zheng M, Wang L, Zhou Y, Yin C, Liu J, Qian L. Re-patterning of H3K27me3, H3K4me3 and DNA methylation during fibroblast conversion into induced cardiomyocytes. Stem Cell Research. 2016 Mar;16(2):507-518.

  11. Zhou Y, Wang L, Vaseghi HR, Liu Z, Lu R, Alimohamadi S, Yin C, Fu JD, Wang GG, Liu J, Qian L. Bmi1 is a key epigenetic barrier to direct cardiac reprogramming. Cell Stem Cell. 2016 Mar 3;18(3):382-395.

    Highlighted in Cell Stem Cell:
    Milad Rezvani, Regina Español-Suñer, Laure Dumont, and Yann Malato, First Author Journal Club: 2016 Selections. Cell Stem Cell. 2016 Jun 2;18(6): 692-694.

    Commented in Stem Cell Investigation:
    Herrero D, Bernad A. Bmi1-mediated epigenetic signature acts as a critical barrier for direct reprogramming to mature cardiomyocytes. Stem Cell Investigation. 2016 Jul 20;3:28.

  12. Wang L, Liu Z, Yin C, Zhou Y, Liu J, Qian L. Improved generation of induced cardiomyocytes using a polycistronic construct expressing optimal ratio of Gata4, Mef2c and Tbx5. Journal of Visualized Experiments. 2015 Nov 13;(105).

Before 2014

  1. Zhou Y, Jiang H, Gu J, Tang Y, Shen N, Jin Y. MicroRNA-195 targets ADP-ribosylation factor-like protein 2 to induce apoptosis in human embryonic stem cell-derived neural progenitor cells. Cell Death & Disease. 2013 Jun 27;4:e695.

    Recommended in F1000Prime:
    Bosnjak Z: F1000Prime Recommendation. In F1000Prime, 11 Jul 2013; DOI: 10.3410/f.718023613.793479605.

  2. Zhou Y, Jin Y. Differentiation of human embryonic stem cells into neural lineage cells. Stem cells and cancer stem cells, Volume 7. Springer Netherlands, 2012: 229-239.

  3. Li H*, Wang B*, Yang A*, Lu R, Wang W, Zhou Y, Shi G, Kwon S, Zhao Y, Jin Y. Ly-1 antibody reactive clone is an important nucleolar protein for control of self-renewal and differentiation in embryonic stem cells. Stem Cells. 2009 Jun;27(6):1244-54. (* co-first authors)